Combined Mesenchymal Stromal Cell Therapy
and ECMO in ARDS
A survey of ECMO practice in 23 Australian Adult ICUs
Bayesian Analyis of EOLIA
Core Outcome Measures Delphi Study
ECMO PT: Early Mobilisation in ECMO
The perceived barriers and facilitators to
implementation of ECMO services in acute hospitals.
Research in Extracorporeal
Life Support: A Call to Action
ECCO2R Position paper
Venoarterial ECMO to
rescue sepsis-induced cardiogenic shock
Drive P Study
A survey of ECMO practice in 23 Australian adult ICUs
Linke NJ, Fulcher BJ, Engeler DM, Anderson S, Bailey MJ, Bernard S, Board JV, Brodie D, Buhr H, Burrell AJC, Cooper DJ, Fan E, Fraser JF, Gattas DJ, Higgins AM, Hopper IK, Huckson S, Litton E, McGuinness SP, Nair P, Orford N, Parke RL, Pellegrino VA, Pilcher DV, Sheldrake J, Reddi BAJ, Stub D, Trapani TV, Udy AA, Hodgson CL; EXCEL Investigators. A survey of extracorporeal membrane oxygenation practice in 23 Australian adult intensive care units. Crit Care Resusc. 2020 Jun;22(2):166-170. PMID: 32389109.
The perceived barriers and facilitators to implementation of ECMO services in acute hospitals.
Fulcher BJ, Nicholson AJ, Linke NJ, Berkovic D, Hodgson CL; EXCEL Study Investigators and the International ECMO Network. The perceived barriers and facilitators to implementation of ECMO services in acute hospitals. Intensive Care Med. 2020 Jul 23. doi: 10.1007/s00134-020-06187-z. Epub ahead of print. PMID: 32705292.
ECMO-PT: Early Mobilisation during ECMO was safe and feasible: a pilot randomised control trial
ECMO-PT Study Investigators; International ECMO Network. Early mobilisation during extracorporeal membrane oxygenation was safe and feasible: a pilot randomised controlled trial. Intensive Care Med. 2020 May;46(5):1057-1059. doi: 10.1007/s00134-020-05994-8. Epub 2020 Mar 16. PMID: 32179935.
Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS
Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF. Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep. Am J Respir Crit Care Med. 2020 Aug 1;202(3):383-392. doi: 10.1164/rccm.201911-2143OC. PMID: 32293914; PMCID: PMC7397785.
Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock
Bréchot N, Hajage D, Kimmoun A, Demiselle J, Agerstrand C, Montero S, Schmidt M, Luyt CE, Lebreton G, Hékimian G, Flecher E, Zogheib E, Levy B, Slutsky AS, Brodie D, Asfar P, Combes A; International ECMO Network. Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study. Lancet. 2020 Aug 22;396(10250):545-552. doi: 10.1016/S0140-6736(20)30733-9. PMID: 32828186.
Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries
Bull T, Corley A, Lye I, Spooner AJ, Fraser JF (2019) Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries. PLoS ONE 14(12): e0227248. https://doi.org/10.1371/journal.pone.0227248
Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice
Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D; International ECMO Network (ECMONet). Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice. Am J Respir Crit Care Med. 2019 Nov 14. doi: 10.1164/rccm.201907-1283CI. [Epub ahead of print]
Core Outcome Measures - Delphi Study
Core Outcome Measures for Research in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation for Acute Respiratory or
Cardiac Failure: An International, Multidisciplinary, Modified Delphi Consensus Study
Hodgson CL, Burrell AJC, Engeler DM, Pellegrino VA, Brodie D, Fan E; On behalf of the International ECMO Network. Core outcome measures for research in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) for acute respiratory failure or cardiac failure: an international, multidisciplinary, modified Delphi consensus study. Crit Care Med 2019;53:98-106.
Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey
Abrams, Darryl, MD; Pham, Tài MD; Burns, Karen E. A. MD; Combes, Alain MD; Curtis, J. Randall MD; Mueller, Thomas MD; Prager, Kenneth M. MD; Serra, Alexis MD; Slutsky, Arthur S. MD; Brodie, Daniel MD; Schmidt, Matthieu MD on behalf of the International ECMO Network (ECMONet). Critical Care Medicine. 2019 July 25: Volume Online First - Issue - p
ETHOS is a prospective, multicenter web-based survey in response to a clinical case vignette. The objectives of the study are to depict practice variation regarding ECMO use, maintenance, withdrawal and determination of futility in severe ARDS in an international cohort of ECMO physicians and identify which physician and hospital-centered factors are related to these practices.
VA ECMO Review
Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications
Burrell AJC, Bennett V, Serra AL, Pellegrino VA, Romero L, Fan E, Brodie D, Cooper DJ, Kaye DM, Fraser JF, Hodgson CL; International ECMO Network (ECMONet). Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications. J Crit Care. 2019 May 24;53:32-37. [Epub ahead of print]
Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort
Schmidt M, Pham T, Arcadipane A, Agerstrand C, Ohshimo S, Pellegrino V, Vuylsteke A, Guervilly C, McGuinness S, Pierard S, Breeding J, Stewart C, Ching SSW, Camuso JM, Stephens RS, King B, Herr D, Schultz MJ, Neuville M, Zogheib E, Mira JP, Rozé H, Pierrot M, Tobin A, Hodgson C, Chevret S, Brodie D, Combes A; International ECMO Network (ECMONet), and the LIFEGARDS Study Group. Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort. Am J Respir Crit Care Med. 2019 May 30. [Epub ahead of print]
Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial
Aubron C, McQuilten Z, Bailey M, Board J, Buhr H, Cartwright B, Dennis M, Hodgson C, Forrest P, McIlroy D, Murphy D, Murray L, Pellegrino V, Pilcher D, Sheldrake J, Tran H, Vallance S, Cooper DJ; endorsed by the International ECMO Network (ECMONet). Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial. Crit Care Med. 2019 Jul;47(7):e563-e571.
Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med 2019; online Feb 21.
ECMO to rescue Lung Injury in severe ARDS
Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. N Engl J Med. 2018 May 24;378(21):1965-1975.
EOLIA is a multicenter, international, randomized, controlled trial run by the REVA network and endorsed by the International ECMO Network. The study hypothesizes that ECMO, instituted early after the diagnosis of very severe ARDS (P:F < 80), would lower the morbidity and mortality associated with this syndrome.
Bayesian Analysis of EOLIA
Goligher EC, Tomlinson G, Hajage D, et al. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial. JAMA. 2018;320(21):2251–2259. doi:10.1001/jama.2018.14276
Cardiac Failure Position Paper
This position paper represents the expert opinion of an international group of physicians, ECMO specialists and allied health-care workers who have expertise relevant to the mechanical circulatory support used to treat patients with severe cardiac failure. The aim of this paper is to provide clinicians, ECMO center directors and coordinators, hospital administrators, healthcare organizations, and regional, national, and international policy makers a consensus approach to the organization of ECMO programs for cardiac failure and cardiac arrest in adults.
Research in Extracorporeal Life Support: A Call to Action
Daniel Brodie, Jean-Louis Vincent, Laurent J. Brochard, Alain Combes, Niall D. Ferguson, Carol L. Hodgson, John G. Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S. Slutsky, V. Marco Ranieri, Jan Bakker, Michael Broome, Jacques Creteur, Daniel De Backer, Luciano Gattinoi, Roberto Lorusso, Stefano Nava, Laurent Papazian, Peter Rimensberger, Claudio Ronco, Robert Sladen, Thomas Staudinger, Fabio Taccone. Research in Extracorporeal Life Support: A Call to Action. Chest. Volume 153, Issue 4. 2018. Pages 788-791.
ECCO2R Position paper
Boyle AJ, Sklar MC, McNamee JJ, et al. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6:874–84.
This position paper represents the expert opinion of an international group of physicians and allied health-care professionals who have expertise relevant to the use of extracorporeal CO2 removal (ECCO2R) in clinical trials and practice. It will provide clinicians, ECCO2R providers, policy makers and clinical researchers with a concise summary of the technology and its use in research and clinical practice. This information informs a summary of recommendations for the use of ECCO2R and areas where there is a requirement for further study.
Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A; International ECMO Network (ECMONet), the REVA Research Network and the IDEA Study Group. Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO. An International Multicenter Retrospective Study. Am J Respir Crit Care Med. 2018 Jan 3. doi: 10.1164/rccm.201708-1761OC. [Epub ahead of print]
This study provides, for the first time, detailed descriptive data on the characteristics, the complication and the outcome of adult’s immunocompromised patients receiving ECMO for ARDS.
Respiratory Failure Position Paper
The aim of this paper is to provide physicians, ECMO center directors and coordinators, hospital directors, health care organizations, regional, national and international policy makers a description of the optimal approach to organizing ECMO programs for acute respiratory failure in adult patients. Importantly, this will help ensure that ECMO is delivered safely and proficiently, such that future observational and randomized clinical trials assessing this technique may be performed by experienced centers under homogeneous and optimal conditions.