Current Research



Antibiotic, Sedative and Analgesic Pharmacokinetics during Extracorporeal Membrane Oxygenation: a multi-centre study to optimise drug therapy during ECMO

This is a multi-centre, open-label, descriptive pharmacokinetic (PK) study.


PRotective vEntilation with veno-venouS lung assisT in respiratory failure

Randomized, allocation concealed, controlled, open, phase 3 pragmatic clinical effectiveness trial to determine whether VV-ECCO2R in mechanically ventilated patients with acute hypoxaemic respiratory failure in intensive care improves mortality at 90 days.


Strategies for Optimal Lung Ventilation in ECMO for ARDS

To assess if a CPAP strategy that minimizes end-tidal pulmonary stress/strain mitigates VILI in comparison to current MV using tidal ventilation in severe ARDS patients on VV ECMO.


Gas eXchange eXtracorporeaL techniques: How many candidates in the ICU?

Prospective, observational study screening patients that meet criteria for ECLS to evaluate the incidence of patients who may be candidates for the different forms of extracorporeal support in ICU.


A Prospective, Multi-Center, Randomized, Controlled, Pivotal Trial to Validate the Safety and Efficacy of the Hemolung® Respiratory Assist System for COPD Patients Experiencing an Acute Exacerbation Requiring Ventilatory Support

This study is being conducted under an FDA approved IDE to establish the safety and efficacy of an investigational Class III medical device for FDA pre-market approval (PMA) via a pivotal RCT to scientifically validate the indication for its use in acute exacerbation of COPD.  The primary objective is to demonstrate the safety and efficacy of using the Hemolung RAS to provide low-flow ECCO2R as an alternative or adjunct to invasive mechanical ventilation versus standard of care invasive mechanical ventilation alone to increase ventilator-free days for COPD patients who require respiratory support due to an acute exacerbation of their COPD.



The International Observational Study on BLood Management for Mechanical Circulatory Support using EXtracorporeal Membrane Oxygenation aims to describe bleeding, thromboembolic complications, blood management and anticoagulation in cardiac ECLS and investigate its associations with morbidity and mortality.

It will identify risk factors for these complications and blood product usage to provide information on current standard of care for future prospective interventional trials.​

The study has started recruitment in late 2019 and centers can express their interest at .


Sub30 pilot





Prospective multicenter Observational study on Transfusion practice in vv-ECMO Patients: The PROTECMO Study is a prospective observational multicenter cohort study. The principal aim is to describe current effective blood product usage, during VV-ECMO. The secondary aim is to describe in a large cohort of ECMO patients the current anticoagulation strategy and bleeding episodes occurrence.



ECMO PT is a multicentre, randomised, trial of whether early individualised physical training (commenced within first 48 hours of ECMO) is feasible and improves functional recovery (the highest level of activity and duration) compared to standard care in ECMO patients.